The database contains its 2000 - 2014 contents only, available for Synthetic Reaction Updates subscribers, the database that has substituted RSC - Methods in Organic Synthesis in 2014.

Each Methods in Organic Synthesis monthly issue contains approximately 200 diagrams selected from key topical journals, covering all areas of synthetic chemistry taking into account new reactions and reagents, asymmetrical synthesis, and enzymatic processing.

The online database is completely searchable and indexed by reaction type, reagent, product, journal, and author. 

Users can register in the database personalizing their profiles with specific settings.